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Projects

Three projects have been established to

  1. use a genomic approach to broadly identify the role of uncharacterized genes
  2. determine the role of envelope integrity with regard to bacterial viability
  3. use expression analysis to identify genes and sRNAs of unknown function associated with drug, disinfectant, and desiccation tolerance

Colin Manoil

Project 1

Project Director: Colin Manoil

Title: Assigning function of unknown genes of Acinetobacter baumannii by use of genetic analysis

Project 1 will identify the gene functions responsible for several such resistance traits, and will identify targets for drugs to enhance the efficacy of established antibiotics in treating A. baumannii infections.

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Sam Miller

Project 2

Project Director: Samuel I. Miller

Title: Assigning function of unknown genes of Acinetobacter baumannii by cell envelope analysis

Project 2 will define genes of unknown function (GUF) of the Gram-negative A. baumannii that contribute to the structure and barrier function of the cell envelope.

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Carrie Harwood

Project 3

Project Director: Caroline S. Harwood

Title: Assigning function to Acinetobacter baumannii sRNA analysis

Project 3 will utilize RNA-seq analysis to identify and define the functions of sRNA regulators (sRNAs) whose expression is associated with resistance traits of A. baumannii.

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