Projects
Three projects have been established to
- use a genomic approach to broadly identify the role of uncharacterized genes
- determine the role of envelope integrity with regard to bacterial viability
- use expression analysis to identify genes and sRNAs of unknown function associated with drug, disinfectant, and desiccation tolerance
Project 1
Project Director: Colin Manoil
Title: Assigning function of unknown genes of Acinetobacter baumannii by use of genetic analysis
Project 1 will identify the gene functions responsible for several such resistance traits, and will identify targets for drugs to enhance the efficacy of established antibiotics in treating A. baumannii infections.
Project 2
Project Director: Samuel I. Miller
Title: Assigning function of unknown genes of Acinetobacter baumannii by cell envelope analysis
Project 2 will define genes of unknown function (GUF) of the Gram-negative A. baumannii that contribute to the structure and barrier function of the cell envelope.
Project 3
Project Director: Caroline S. Harwood
Title: Assigning function to Acinetobacter baumannii sRNA analysis
Project 3 will utilize RNA-seq analysis to identify and define the functions of sRNA regulators (sRNAs) whose expression is associated with resistance traits of A. baumannii.
